Erratum to: Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy
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assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
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15 صفحه اولCrystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination.
Deoxyhypusine hydroxylase (DOHH) is a non-heme diiron enzyme involved in the posttranslational modification of a critical lysine residue of eukaryotic translation initiation factor 5A (eIF-5A) to yield the unusual amino acid residue hypusine. This modification is essential for the role of eIF-5A in translation and in nuclear export of a group of specific mRNAs. The diiron center of human DOHH (...
متن کاملModelling and Simulation to Improve Antimalarial Therapy
Lohy Das, J. P. 2017. Modelling and Simulation to Improve Antimalarial Therapy. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 239. 75 pp. Upppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0098-6. The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Des...
متن کاملgene expression profiling for cancer targeted therapy
background : lung cancer is still the leading cause of cancer- related deaths and most of themâ are normally diagnosed in late stages, so there is an urgent need to establish reliable tools for the identification at early stages of the disease. in this study, we use an eleven gene signature test to examine lung biopsy specimens for diagnostic, prognostic & therapeutic purposes. methods : bronc...
متن کاملIron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.
Although cells express hundreds of metalloenzymes, the mechanisms by which apoenzymes receive their metal cofactors are largely unknown. Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center. Here, we show that PCBP1 and PCBP2 also deliv...
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ژورنال
عنوان ژورنال: Amino Acids
سال: 2014
ISSN: 0939-4451,1438-2199
DOI: 10.1007/s00726-014-1689-z